Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow. The anticancer activity is induced by xanthones such as alpha-, beta-, and gamma-mangostin which are major constituents of the pericarp of mangosteen fruits. In order to obtain the biological active compound, α-mangostin, from the traditional native mangosteen (Garcinia mangostana L.), an extraction.

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The results of immunohistochemical analysis of cleaved caspase-3 were similar to those of western blot analysis Fig. Mangosteen Garcinia mangostana L.


A comparative study of effects of aversectin C abamectin and ivermectin on apoptosis of rat thymo-cytes induced by radiation and dexamethasone. Bcl-2 family proteins control membrane permeability and are located in the mitochondrial membrane or move to the mitochondrial membrane to induce apoptotic cell death Both caspase-3 and -9 were activated, as evidenced by the increased levels of the respective cleaved forms, as well as PARP segmentation Fig.

International Journal of Molecular Medicine. Chemical constituents of Garcinia mangostana. Moreover, the observed increases were concentration-dependent. The cells were then washed twice and resuspended in RPMI medium.

On day alphs, mice were sacrificed and tumors excised.

This article is mentioned in: Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki Bax and Bad are pro-apoptotic factors that promote apoptosis, whereas Bcl-2 is an anti-apoptotic factor 31 Oral cancer poses a risk of invasion to adjacent organs and a higher possibility of metastatic relapse. Moreover, the number of viable cells decreased in a concentration-dependent manner.


A clinicostatistical analysis of oral cancer patients for recent 8 years. Initiator caspases are activated by death signals to further activate the effector caspases B Membranes incubated with the anti-Bcl-2 antibody.

The apoptotic cells were analyzed quantitatively by flow cytometry to determine whether the morphological changes observed in the DAPI-stained chromosomes were caused by apoptosis. In some studies, it was reported that several naturally derived substances induce apoptosis and inhibit cancer cell growth 21 — Alpja Q and Shi Y: Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia HL cells.

The cells treated with International Journal of Molecular Medicine Sign up for eToc alerts. The percentage of sub-G1 mangostjn in the control group was 0.

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Surgical therapies, radiation therapies, medications and other current treatments for oral cancer are associated with a low treatment efficacy and severe adverse effects; thus, in general, oral cancer has a poor prognosis.

Thus, as regards the development of particular anticancer drugs and preventive medications, the extent that a substance affects cancer cell cycle progression should be identified.



The mitogen-activated protein kinase MAPK cascade, a pathway used to send external signals to internal cells, is involved in various processes, including cell proliferation and fragmentation, apoptosis and survival. Cancer statistics in Korea: Significance was determined by Dunnett’s t-test. A portion of the tumor was embedded in paraffin and used for TUNEL aopha and immunohistochemical analysis.

In other words, an increase in the proportion of mangosgin cells reflects an increase in apoptosis. This is an open access article distributed under the terms of Creative Commons Attribution License. The absorbance of the solutions at nm was determined using a microplate reader Bio-Rad Laboratories, Inc. The culture medium was replaced every 2—3 days.

Another key component of the MAPK pathway, p38 MAPK, is activated by chemical and environmental stresses and inflammatory factors that affect cellular levels Int J Mol Mangostun. Oral cancer and precancerous lesions. A Membranes incubated with the anti-Bax antibody.

CA Cancer J Clin. Statistical significance was determined by the Dunnett’s t-test. The Mangosgin apoptotic pathway. Xanthones from mangosteen extracts as natural chemopreventive agents: Differences between mean values for the individual groups were assessed by one-way analysis of variance ANOVA with Dunnett’s t-tests. Cell Mol Biol Res.