George Nicholas Papanicolaou was born in Kimi on the island of Euboea. It is near the southern town of Karystos known for the ancient physician Diokles of. Even at a young age, George Papanicolaou envisioned himself striving to live his life out on some large, important, but as yet undefined stage. After receiving his. Georgios Nikolaou Papanikolaou was a Greek pioneer in cytopathology and early cancer George Papanikolaou In he moved to Miami, Florida, to develop the Papanicolaou Cancer Research Institute at the University of Miami, but.

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This was the first screening test to diagnose cervical and uterine cancer. He thus became known for his invention of the Papanicolaou test, commonly known as the Pap smear or Pap testwhich is used worldwide for the detection and prevention of cervical cancer and other cytologic diseases of the female reproductive system.

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George Nicholas Papanicolaou was born in Kimi on the island of Euboea. Papanicolaou and Herbert Traut: However, this potential medical breakthrough was initially met with scepticism and resistance from the scientific community, and it was not until the early s that large-scale screening using Pap smear began.

Papanicolaou obtained American citizenship in Much of his work was done in collaboration with the biochemist Charles Rupert Stockard and E. InPapanicolaou became Emeritus Professor at what was then Cornell University Medical College, where two laboratories now bear his name. Papanicolaou first reported in that he could recognise cancer cells ppapanicolaou the importance of his findings was not generally accepted and he abandoned the work for some years.


George Papanicolaou (–): Discoverer of the Pap smear

In Papanikolaou told an incredulous audience of physicians about the noninvasive technique of gathering cellular debris from the lining of the vaginal tract and smearing it on a glass slide for microscopic examination as a way to identify cervical cancer.

These milestones include the discovery of the electron microscope in ; the concept of cell theory; the techniques of fixing, staining, and mounting specimens; and finally the realization that, from the study of cells or tiny tissue fragments on a slide, one can often distinguish between healthy and diseased bodily changes.

Author information Copyright and License information Disclaimer. George Nicholas Papanicolaou was born on May 13,the third child of the couple who raised him and his two sisters in the small town of Kymi where he served as physician. Smear diagnosis of carcinoma of the cervix. Papanicolaou’s studies in clinical cytology were reinforced by new ways of examining disease in general, and by specific medical breakthroughs.

User Account Personal Profile: Individuals Law and crime Manufacture and trade Media and performing arts Medicine and health. This page was last edited on 22 Decemberat In female guinea pigs, Papanicolaou had already noticed cell transformation and wanted to corroborate the phenomenon in human females.

You do not currently have access to this article Login Please login to access the full content. Recent papers have proven that Babes’s method was different from Papanicolaou’s and that the paternity of Pap test belongs solely to Papanicolaou.

That honour goes to British physician Walter Hayle Walshe, who referred to this phenomenon in a book on lung diseases one century before. Retrieved from ” https: In countries where Pap smears are routine clinical practice, cervical cancer rates have dropped dramatically, and the screening test is credited as one of the greatest life-saving techniques in medical practice.


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In he received the Ph. He is best known for creating the Papanicolaou test, commonly known as the Pap smear, which revolutionised the early detection of cervical cancer. In total, Papanicolaou authored four books and over one hundred articles. Please review our privacy policy. Please login to access the full content.

For the next two years, he cared for leprosy patients on the outskirts of his hometown.

Therefore, although Babes publication preceded Papanicolaou, the design of the Pap test belongs to Papanicolaou since he had already tried it in in “Women’s Hospital”. He subsequently researched the human female menstrual cycle cytology and used his techniques to examine cells for cancer in ; he then presented and published about the same thing in humans in β€”to a skeptical paoanicolaou of surgeons. Nikolas and Maria Papanicolaou.

His research was devoted almost exclusively to the physiology of reproduction and exfoliative papanlcolaou, at the New York Hospital and the Cornell Medical College, two affiliated institutions, each of which has named a laboratory in his honour.

In an attempt papabicolaou test his theories in humans, Papanicolaou undertook a study of human vaginal smears. During this time, he developed his method of preservation of these cells by wet fixation and precise staining. Papanikolaou’s portrait appeared on the obverse of the Greek 10, drachma banknote of β€”, [9] prior to its replacement by the euro.